Hypertensive pathologies and pregnancies resulting from egg donation.

Abstract

In vitro fertilization with oocyte donation has
become a very widespread medically assisted
reproductive technique for couple management,
when the woman suffers from pathological or physiological ovarian failure, or has a genetic disease
that could be transmitted with particularly severe
risk for her child. Based on a literature review,
pregnancies resulting from oocyte donation are significantly associated with certain diseases such as
all types of gestational hypertensive disorders,
including potentially severe ones, like preeclampsia, whose onset is independent of the mother’s
age, and numbers of pregnancies and/or fetuses.
The most likely hypothesis to explain gestational
hypertension is modification of immune tolerance
of the embryo, whose entire genome is allogeneic
to the mother’s. While awaiting the results of larger
ongoing studies, it is now essential to consider every
oocyte-donation-derived pregnancy as being at
high vascular risk to assure close monitoring of its
progress.