Preeclampsia, genetics and oxidative stress

Abstract

Many articles have suggested a significant impact
of oxidative stress and disorders of mitochondrial
function in preeclampsia. This review examines the
reasons suggesting that the mechanisms altering
the management of oxidative stress are primarily
linked with preeclampsia and placental disorders.
It ends with the presentation of a mouse model of
preeclampsia in which equilibrium of the ‘nitrosoredox’ balance is completely disrupted. This model
could be used for the detailed understanding of
some cases of human disease.